Subchronic toxicity of PCB 105 (2,3,3′,4,4′‐pentachlorobiphenyl) in rats
Identifieur interne : 003938 ( Main/Exploration ); précédent : 003937; suivant : 003939Subchronic toxicity of PCB 105 (2,3,3′,4,4′‐pentachlorobiphenyl) in rats
Auteurs : I. Chu [Canada] ; R. Poon [Canada] ; A. Yagminas [Canada] ; P. Lecavalier [Canada] ; H. H Kansson [Suède] ; V. E. Valli [États-Unis] ; S. W. Kennedy [Canada] ; Bergman [Suède] ; R. F. Seegal [États-Unis] ; M. Feeley [Canada]Source :
- Journal of Applied Toxicology [ 0260-437X ] ; 1998-07.
English descriptors
Abstract
The toxicity of 2,3,3′,4,4′‐pentachlorobiphenyl (PCB 105) was investigated in Sprague‐Dawley rats following dietary exposure to this substance at levels of 0, 0.05, 0.5, 5 or 50 ppm for 13 weeks. Growth rate and food consumption were not affected and no clinical signs of toxicity were observed. Increased incidences of enlarged, fatty liver and decreased thymic weight were observed in the highest‐dose groups of both genders; these groups also had elevated hepatic microsomal ethoxyresorufin deethylase activity and uroporphyrin. Significant increases in serum cholesterol and hepatic pentoxyresorufin dealkylase activity were observed in the highest‐dose males and two highest‐dose females. By contrast, liver UDP‐glucuronosyl transferase activity was elevated in the two highest‐dose males and the highest‐dose females. Urinary ascorbic acid excretion was increased in the highest‐dose males. While the amount of vitamin A was decreased dose‐dependently, starting at 0.5 ppm in the liver of both sexes and in the lung of the females, the level in the kidney of the highest‐dose group was increased. Administration of PCB 105 resulted in decreased dopamine in the caudate nucleus region of the brain in males and homovanillic acid in caudate nucleus and nucleus accumbens of females. Increased 5‐hydroxytryptamine and 5‐hydroxyindoleacetic acid were observed in the substantia nigra region of both sexes, with most of the increases being seen in highest‐dose females. Anemia, characterized by decreased hemoglobin, hematocrit and red cell indices, occurred in the highest‐dose group, as did eosinophilia. Treatment with PCB 105 caused dose‐dependent histopathological changes in the liver and thyroid. Thymic changes were observed in the highest‐dose males and two highest‐dose females. Tissue residue data showed a dose‐dependent accumulation of this congener in fat, liver and spleen, kidney and brain. Based on these data the no‐observable‐effect level of PCB 105 was judged to be 0.05 ppm or 3.9 μg kg−1 body wt. day−1 in males and 4.2 μg kg−1 body wt. day−1 in females. © 1998 John Wiley & Sons, Ltd.
Url:
DOI: 10.1002/(SICI)1099-1263(199807/08)18:4<285::AID-JAT510>3.0.CO;2-9
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000933
- to stream Istex, to step Curation: 000933
- to stream Istex, to step Checkpoint: 001496
- to stream Main, to step Merge: 003F53
- to stream Main, to step Curation: 003938
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Subchronic toxicity of PCB 105 (2,3,3′,4,4′‐pentachlorobiphenyl) in rats</title><author><name sortKey="Chu, I" sort="Chu, I" uniqKey="Chu I" first="I." last="Chu">I. Chu</name></author><author><name sortKey="Poon, R" sort="Poon, R" uniqKey="Poon R" first="R." last="Poon">R. Poon</name></author><author><name sortKey="Yagminas, A" sort="Yagminas, A" uniqKey="Yagminas A" first="A." last="Yagminas">A. Yagminas</name></author><author><name sortKey="Lecavalier, P" sort="Lecavalier, P" uniqKey="Lecavalier P" first="P." last="Lecavalier">P. Lecavalier</name></author><author><name sortKey="H Kansson, H" sort="H Kansson, H" uniqKey="H Kansson H" first="H." last="H Kansson">H. H Kansson</name></author><author><name sortKey="Valli, V E" sort="Valli, V E" uniqKey="Valli V" first="V. E." last="Valli">V. E. Valli</name></author><author><name sortKey="Kennedy, S W" sort="Kennedy, S W" uniqKey="Kennedy S" first="S. W." last="Kennedy">S. W. Kennedy</name></author><author><name sortKey="Bergman, " sort="Bergman, " uniqKey="Bergman " first="" last="Bergman"> Bergman</name></author><author><name sortKey="Seegal, R F" sort="Seegal, R F" uniqKey="Seegal R" first="R. F." last="Seegal">R. F. Seegal</name></author><author><name sortKey="Feeley, M" sort="Feeley, M" uniqKey="Feeley M" first="M." last="Feeley">M. Feeley</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:CF610D502B1D52B1E3FBFF7AAFA55F2F346DE36E</idno><date when="1998" year="1998">1998</date><idno type="doi">10.1002/(SICI)1099-1263(199807/08)18:4<285::AID-JAT510>3.0.CO;2-9</idno><idno type="url">https://api-v5.istex.fr/document/CF610D502B1D52B1E3FBFF7AAFA55F2F346DE36E/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000933</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000933</idno><idno type="wicri:Area/Istex/Curation">000933</idno><idno type="wicri:Area/Istex/Checkpoint">001496</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001496</idno><idno type="wicri:doubleKey">0260-437X:1998:Chu I:subchronic:toxicity:of</idno><idno type="wicri:Area/Main/Merge">003F53</idno><idno type="wicri:Area/Main/Curation">003938</idno><idno type="wicri:Area/Main/Exploration">003938</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Subchronic toxicity of PCB 105 (2,3,3′,4,4′‐pentachlorobiphenyl) in rats</title><author><name sortKey="Chu, I" sort="Chu, I" uniqKey="Chu I" first="I." last="Chu">I. Chu</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Health Protection Branch, Tunney's Pasture, Ottawa, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Health Protection Branch, Tunney's Pasture, Ottawa, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Poon, R" sort="Poon, R" uniqKey="Poon R" first="R." last="Poon">R. Poon</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Health Protection Branch, Tunney's Pasture, Ottawa, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Yagminas, A" sort="Yagminas, A" uniqKey="Yagminas A" first="A." last="Yagminas">A. Yagminas</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Health Protection Branch, Tunney's Pasture, Ottawa, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Lecavalier, P" sort="Lecavalier, P" uniqKey="Lecavalier P" first="P." last="Lecavalier">P. Lecavalier</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Health Protection Branch, Tunney's Pasture, Ottawa, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="H Kansson, H" sort="H Kansson, H" uniqKey="H Kansson H" first="H." last="H Kansson">H. H Kansson</name><affiliation wicri:level="3"><country xml:lang="fr">Suède</country><wicri:regionArea>Division of Environmental Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Valli, V E" sort="Valli, V E" uniqKey="Valli V" first="V. E." last="Valli">V. E. Valli</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>College of Veterinary Medicine, University of Illinois, Urbana, IL</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Kennedy, S W" sort="Kennedy, S W" uniqKey="Kennedy S" first="S. W." last="Kennedy">S. W. Kennedy</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Canadian Wildlife Service, Environment Canada, Hull, Quebec</wicri:regionArea><wicri:noRegion>Quebec</wicri:noRegion></affiliation></author><author><name sortKey="Bergman, " sort="Bergman, " uniqKey="Bergman " first="" last="Bergman"> Bergman</name><affiliation wicri:level="3"><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Environmental Chemistry, Wallenberg Laboratory, University of Stockholm, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Seegal, R F" sort="Seegal, R F" uniqKey="Seegal R" first="R. F." last="Seegal">R. F. Seegal</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>New York State Department of Health, Wadsworth Centre for Laboratory and Research, Albany, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Feeley, M" sort="Feeley, M" uniqKey="Feeley M" first="M." last="Feeley">M. Feeley</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Health Protection Branch, Tunney's Pasture, Ottawa, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Applied Toxicology</title><title level="j" type="sub">An International Forum Devoted to Research and Methods Emphasizing Direct Clinical, Industrial and Environmental Applications</title><title level="j" type="abbrev">J. Appl. Toxicol.</title><idno type="ISSN">0260-437X</idno><idno type="eISSN">1099-1263</idno><imprint><publisher>John Wiley & Sons, Ltd.</publisher><pubPlace>Chichester</pubPlace><date type="published" when="1998-07">1998-07</date><biblScope unit="volume">18</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="285">285</biblScope><biblScope unit="page" to="292">292</biblScope></imprint><idno type="ISSN">0260-437X</idno></series><idno type="istex">CF610D502B1D52B1E3FBFF7AAFA55F2F346DE36E</idno><idno type="DOI">10.1002/(SICI)1099-1263(199807/08)18:4<285::AID-JAT510>3.0.CO;2-9</idno><idno type="ArticleID">JAT510</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0260-437X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>2,3,3′,4,4′‐pentachlorobiphenyl</term><term>PCB 105</term><term>rat</term><term>subchronic toxicity</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The toxicity of 2,3,3′,4,4′‐pentachlorobiphenyl (PCB 105) was investigated in Sprague‐Dawley rats following dietary exposure to this substance at levels of 0, 0.05, 0.5, 5 or 50 ppm for 13 weeks. Growth rate and food consumption were not affected and no clinical signs of toxicity were observed. Increased incidences of enlarged, fatty liver and decreased thymic weight were observed in the highest‐dose groups of both genders; these groups also had elevated hepatic microsomal ethoxyresorufin deethylase activity and uroporphyrin. Significant increases in serum cholesterol and hepatic pentoxyresorufin dealkylase activity were observed in the highest‐dose males and two highest‐dose females. By contrast, liver UDP‐glucuronosyl transferase activity was elevated in the two highest‐dose males and the highest‐dose females. Urinary ascorbic acid excretion was increased in the highest‐dose males. While the amount of vitamin A was decreased dose‐dependently, starting at 0.5 ppm in the liver of both sexes and in the lung of the females, the level in the kidney of the highest‐dose group was increased. Administration of PCB 105 resulted in decreased dopamine in the caudate nucleus region of the brain in males and homovanillic acid in caudate nucleus and nucleus accumbens of females. Increased 5‐hydroxytryptamine and 5‐hydroxyindoleacetic acid were observed in the substantia nigra region of both sexes, with most of the increases being seen in highest‐dose females. Anemia, characterized by decreased hemoglobin, hematocrit and red cell indices, occurred in the highest‐dose group, as did eosinophilia. Treatment with PCB 105 caused dose‐dependent histopathological changes in the liver and thyroid. Thymic changes were observed in the highest‐dose males and two highest‐dose females. Tissue residue data showed a dose‐dependent accumulation of this congener in fat, liver and spleen, kidney and brain. Based on these data the no‐observable‐effect level of PCB 105 was judged to be 0.05 ppm or 3.9 μg kg−1 body wt. day−1 in males and 4.2 μg kg−1 body wt. day−1 in females. © 1998 John Wiley & Sons, Ltd.</div></front></TEI><affiliations><list><country><li>Canada</li><li>Suède</li><li>États-Unis</li></country><region><li>Illinois</li><li>Svealand</li><li>État de New York</li></region><settlement><li>Stockholm</li></settlement></list><tree><country name="Canada"><noRegion><name sortKey="Chu, I" sort="Chu, I" uniqKey="Chu I" first="I." last="Chu">I. Chu</name></noRegion><name sortKey="Chu, I" sort="Chu, I" uniqKey="Chu I" first="I." last="Chu">I. Chu</name><name sortKey="Feeley, M" sort="Feeley, M" uniqKey="Feeley M" first="M." last="Feeley">M. Feeley</name><name sortKey="Kennedy, S W" sort="Kennedy, S W" uniqKey="Kennedy S" first="S. W." last="Kennedy">S. W. Kennedy</name><name sortKey="Lecavalier, P" sort="Lecavalier, P" uniqKey="Lecavalier P" first="P." last="Lecavalier">P. Lecavalier</name><name sortKey="Poon, R" sort="Poon, R" uniqKey="Poon R" first="R." last="Poon">R. Poon</name><name sortKey="Yagminas, A" sort="Yagminas, A" uniqKey="Yagminas A" first="A." last="Yagminas">A. Yagminas</name></country><country name="Suède"><region name="Svealand"><name sortKey="H Kansson, H" sort="H Kansson, H" uniqKey="H Kansson H" first="H." last="H Kansson">H. H Kansson</name></region><name sortKey="Bergman, " sort="Bergman, " uniqKey="Bergman " first="" last="Bergman"> Bergman</name></country><country name="États-Unis"><region name="Illinois"><name sortKey="Valli, V E" sort="Valli, V E" uniqKey="Valli V" first="V. E." last="Valli">V. E. Valli</name></region><name sortKey="Seegal, R F" sort="Seegal, R F" uniqKey="Seegal R" first="R. F." last="Seegal">R. F. Seegal</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003938 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003938 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:CF610D502B1D52B1E3FBFF7AAFA55F2F346DE36E
|texte= Subchronic toxicity of PCB 105 (2,3,3′,4,4′‐pentachlorobiphenyl) in rats
}}
| This area was generated with Dilib version V0.6.29. |  |